Protective Effects of Metformin on Renal Tubular Cells

protective effects of metformin on renal tubular cells

Protective Effects of Metformin on Renal Tubular Cells

Recently, we conducted a preclinical investigation to find the ameliorative properties of metformin on renal biochemical and histologic alterations of gentamicininduced kidney damage in male Wistar rats (1). In this investigation, attenuation of gentamicin-induced acute kidney injury was found. Likewise, Taheri et al. conducted a study on the effects of metformin on renal tubular cells after un...

Protective effects of Zhibai Dihuang Wan on renal tubular cells affected with gentamicin-induced apoptosis.

ETHNOPHARMACOLOGICAL RELEVANCE Zhibai Dihuang Wan (ZDW) is an ancient traditional Chinese medicine composed of eight herbal ingredients and has been used to treat chronic kidney inflammation and diabetes for thousands of years. Nonetheless, the influence of ZDW on acute kidney injury is still unknown. We intended to identify the influence of ZDW on cell growth and gentamicin-induced apoptotic i...

Tangeretin protects renal tubular epithelial cells against experimental cisplatin toxicity

Objective(s): Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.Materials and Methods: Tangeretin was injected intra...

The protective effects of ischemic postconditioning on renal tubular epithelial Epithelial-mesenchymal transition

Renal tubular Epithelial-mesenchymal transition (EMT) plays an important role in the process of renal fibrosis. The aim of this study is to observe the effects of ischemia post-conditioning on renal tubular Epithelialmesenchymal transition in vitro. A valid in vitro ischemia post-conditioning model was established by using NRK-52E cell line. The ischemic postconditioning (IPO) model was establi...